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Proteasome Maturation Protein (POMP)

PNAS-110; UMP1; Proteassemblin; Protein UMP1 homolog; Voltage-gated K channel beta subunit 4.1

Proteasome maturation protein is a short-lived maturation factor required for 20S proteasome subunit biogenesis. Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation.
Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i has been observed in Ref.11, but not in Ref.9. Forms tetramers. Ref.15

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Hu01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Hu01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Hu01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Hu01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Hu01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Mu01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Mu01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Mu01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Mu01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Mu01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Ra01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Ra01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Ra01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Ra01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Ra01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Ca01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Ca01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Ca01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Ca01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Ca01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Po01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Po01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Po01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Po01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Po01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Bo01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Bo01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Bo01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Bo01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Bo01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Rb01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Rb01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Rb01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Rb01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Rb01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU126Mo01 Recombinant Proteasome Maturation Protein (POMP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU126Mo01 Monoclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IP.
PAU126Mo01 Polyclonal Antibody to Proteasome Maturation Protein (POMP) WB; IHC; ICC; IF.
Assay Kits CLU126Mo01 CLIA Kit for Proteasome Maturation Protein (POMP) CLIA assay for Antigen Detection
ELU126Mo01 ELISA Kit for Proteasome Maturation Protein (POMP) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis."
Am. J. Hum. Genet. 86:596-603(2010) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes."
J. Mol. Biol. 301:1-9(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of proteassemblin, a mammalian homologue of the yeast protein, Ump1p, that is required for normal proteasome assembly."
Mol. Cell Biol. Res. Commun. 3:212-217(2000) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a mammalian protein interacting with 20S proteasome precursors."
Proc. Natl. Acad. Sci. U.S.A. 97:10348-10353(2000) [PubMed] [Europe PMC] [Abstract]

"Protein-protein interactions among human 20S proteasome subunits and proteassemblin."
Biochem. Biophys. Res. Commun. 314:523-528(2004) [PubMed] [Europe PMC] [Abstract]

"A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes."
Nature 437:1381-1385(2005) [PubMed] [Europe PMC] [Abstract]

"IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response."
Proc. Natl. Acad. Sci. U.S.A. 102:9241-9246(2005) [PubMed] [Europe PMC] [Abstract]

"Possible tetramerisation of the proteasome maturation factor POMP/proteassemblin/hUmp1 and its subcellular localisation."
Int. J. Biol. Macromol. 38:259-267(2006) [PubMed] [Europe PMC] [Abstract]

"The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum."
EMBO Rep. 8:1170-1175(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]