Phosphoserine Phosphatase (PSPH)
PSP; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase
- Phosphoserine phosphatase is an enzyme belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.
- The 3 substrates of this enzyme are O-phospho-L-serine, O-phospho-D-serine, and H2O, whereas its 3 products are L-serine, D-serine, and phosphate.This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is O-phosphoserine phosphohydrolase.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Hu01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Hu01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Hu01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Hu01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Hu01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Mu01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Mu01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Mu01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Mu01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Mu01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Ra01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Ra01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Ra01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Ra01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Ra01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Ca01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Ca01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Ca01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Ca01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Ca01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Po01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Po01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Po01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Po01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Po01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Bo01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Bo01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Bo01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Bo01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Bo01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Rb01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Rb01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Rb01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Rb01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Rb01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU121Mo01 | Recombinant Phosphoserine Phosphatase (PSPH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU121Mo01 | Monoclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IP. |
| PAU121Mo01 | Polyclonal Antibody to Phosphoserine Phosphatase (PSPH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU121Mo01 | CLIA Kit for Phosphoserine Phosphatase (PSPH) | CLIA assay for Antigen Detection |
| ELU121Mo01 | ELISA Kit for Phosphoserine Phosphatase (PSPH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate."
FEBS Lett. 408:281-284(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase."
J. Biol. Chem. 277:46651-46658(2002) [PubMed] [Europe PMC] [Abstract]
"High-resolution structure of human phosphoserine phosphatase in open conformation."
Acta Crystallogr. D 59:971-977(2003) [PubMed] [Europe PMC] [Abstract]
"How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase."
Eur. J. Biochem. 271:3421-3427(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations responsible for 3-phosphoserine phosphatase deficiency."
Eur. J. Hum. Genet. 12:163-166(2004) [PubMed] [Europe PMC] [Abstract]