Polypyrimidine Tract Binding Protein 1 (PTBP1)

HNRNPI; HNRPI; PTB; PTB-T; PTB2; PTB3; PTB4; pPTB; Heterogeneous Nuclear Ribonucleoprotein I; 57 kDa RNA-binding protein PPTB-1

SPN	U120
HGNC	9583
MGI	97791
PubMed	24418892
RGD	62047
UniProt	P26599
Wiki	PTBP1

Polypyrimidine tract-binding protein 1 is a protein belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).

The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Reference

"Characterization of cDNAs encoding the polypyrimidine tract-binding protein."
Genes Dev. 5:1224-1236(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing."
Genes Dev. 5:1237-1251(1991) [PubMed] [Europe PMC] [Abstract]

"hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs."
Nucleic Acids Res. 20:3671-3678(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]