Pituitary Tumor Transforming 1 (PTTG1)

EAP1; HPTTG; PTTG; TUTR1; Securin; ESP1-Associated Protein 1; Tumor-Transforming Protein 1

SPN	U118
HGNC	9690
MGI	1353578
PubMed	20198633
RGD	68359
UniProt	O95997
Wiki	PTTG1

Securin is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Reference

"hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG."
Oncogene 17:2187-2193(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis."
Cytogenet. Cell Genet. 84:211-216(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)."
Gene 240:317-324(1999) [PubMed] [Europe PMC] [Abstract]

"Structure, expression, and function of human pituitary tumor-transforming gene (PTTG)."
Mol. Endocrinol. 13:156-166(1999) [PubMed] [Europe PMC] [Abstract]

"Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas."
J. Clin. Endocrinol. Metab. 84:761-767(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis."
Science 285:418-422(1999) [PubMed] [Europe PMC] [Abstract]

"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]

"Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase."
Nucleic Acids Res. 29:1300-1307(2001) [PubMed] [Europe PMC] [Abstract]

"Securin is required for chromosomal stability in human cells."
Cell 105:445-457(2001) [PubMed] [Europe PMC] [Abstract]

"Human pituitary tumor-transforming gene induces angiogenesis."
J. Clin. Endocrinol. Metab. 86:867-874(2001) [PubMed] [Europe PMC] [Abstract]

"Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis."
Nat. Genet. 32:306-311(2002) [PubMed] [Europe PMC] [Abstract]

"Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product."
Oncogene 19:403-409(2000) [PubMed] [Europe PMC] [Abstract]

"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
Cell 133:653-665(2008) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]