Quinoid Dihydropteridine Reductase (QDPR)

DHPR; PKU2; SDR33C1; HDHPR; 6,7-Dihydropteridine Reductase; Short Chain Dehydrogenase/Reductase Family 33C,Member 1

SPN	U099
HGNC	9752
MGI	97836
PubMed	9744478
RGD	619915
UniProt	P09417
Wiki	QDPR

QDPR (quinoid dihydropteridine reductase) is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4. Tetrahydrobiopterin works with an enzyme called phenylalanine hydroxylase to process a substance called phenylalanine. Phenylalanine is an amino acid (a building block of proteins) that is obtained through the diet; it is found in all proteins and in some artificial sweeteners. When tetrahydrobiopterin interacts with phenylalanine hydroxylase, tetrahydrobiopterin is altered and must be recycled to a usable form. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells.

Reference

"Human dihydropteridine reductase: characterisation of a cDNA clone and its use in analysis of patients with dihydropteridine reductase deficiency."
Nucleic Acids Res. 15:1921-1932(1987) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of human dihydropteridine reductase."
Proc. Natl. Acad. Sci. U.S.A. 84:3329-3333(1987) [PubMed] [Europe PMC] [Abstract]

"Dihydropteridine reductase deficiency: physical structure of the QDPR gene, identification of two new mutations and genotype-phenotype correlations."
Hum. Mutat. 12:267-273(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]