Retinaldehyde Binding Protein 1 (RLBP1)

CRALBP; Cellular retinaldehyde-binding protein

SPN	U081
HGNC	10024
MGI	97930
PubMed	14718298
RGD	1309649
UniProt	P12271
Wiki	RLBP1

Retinaldehyde-binding protein 1 is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. CRALBP is not expressed in photoreceptors but is abundant in the retinal pigment epithelium (RPE) and Muller cells of the neuroretina, where it carries 11-cis-retinol and 11-cis-retinaldehyde. When expressed in bacteria, recombinant CRALBP containing the R150Q substitution was less soluble than wildtype recombinant CRALBP. Mutant CRALBP was purified and found to lack the ability to bind 11-cis-retinaldehyde.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Hu01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Hu01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Hu01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Hu01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Hu01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Mu01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Mu01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Mu01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Mu01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Mu01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Ra01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Ra01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Ra01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Ra01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Ra01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Ca01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Ca01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Ca01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Ca01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Ca01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Po01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Po01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Po01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Po01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Po01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Bo01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Bo01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Bo01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Bo01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Bo01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Rb01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Rb01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Rb01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Rb01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Rb01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU081Mo01	Recombinant Retinaldehyde Binding Protein 1 (RLBP1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU081Mo01	Monoclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IP.
Antibodies	PAU081Mo01	Polyclonal Antibody to Retinaldehyde Binding Protein 1 (RLBP1)	WB; IHC; ICC; IF.
Assay Kits	CLU081Mo01	CLIA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	CLIA assay for Antigen Detection
Assay Kits	ELU081Mo01	ELISA Kit for Retinaldehyde Binding Protein 1 (RLBP1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures."
J. Biol. Chem. 263:18688-18692(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and structural analysis of the human gene encoding cellular retinaldehyde-binding protein."
J. Biol. Chem. 269:25411-25418(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein."
Protein Sci. 7:746-757(1998) [PubMed] [Europe PMC] [Abstract]

"Newfoundland rod-cone dystrophy, an early-onset retinal dystrophy, is caused by splice-junction mutations in RLBP1."
Am. J. Hum. Genet. 70:955-964(2002) [PubMed] [Europe PMC] [Abstract]

"Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W."
Proc. Natl. Acad. Sci. U.S.A. 106:18545-18550(2009) [PubMed] [Europe PMC] [Abstract]

"Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa."
Nat. Genet. 17:198-200(1997) [PubMed] [Europe PMC] [Abstract]

"Bothnia dystrophy caused by mutations in the cellular retinaldehyde-binding protein gene (RLBP1) on chromosome 15q26."
Invest. Ophthalmol. Vis. Sci. 40:995-1000(1999) [PubMed] [Europe PMC] [Abstract]

"Recessive mutations in the RLBP1 gene encoding cellular retinaldehyde-binding protein in a form of retinitis punctata albescens."
Invest. Ophthalmol. Vis. Sci. 40:1000-1004(1999) [PubMed] [Europe PMC] [Abstract]