Tachykinin, Precursor 1 (TAC1)

NK2; NKNA; NKA; TAC2; •PPT; Protachykinin-1; Substance P; Neurokinin A; Neuromedin L; Substance K; Neuropeptide K; Neuropeptide gamma; C-terminal-flanking peptide

SPN	U077
HGNC	11517
MGI	98474
PubMed	17908158
RGD	3807
UniProt	P20366
Wiki	TAC1

Protachykinin-1 is a protein encoded by the TAC1 gene.Tachykinins are a family of peptides that have similar biologic activities and share a common C-terminal sequence, phe-X-gly-leu-met-NH2, but have distinct N-terminal sequences that convey receptor specificities. Members of this family include substance P, neurokinin A , and neurokinin B (TAC3). The TAC1 gene encodes both substance P and neurokinin A.Krause et al. (1987) showed that 3 forms of preprotachykinin mRNAs, designated alpha, beta, and gamma, arise by alternative splicing events in rat. The beta and gamma forms encode both substance P and neurokinin A, while the alpha form contains only the substance P sequence.Using probes derived from the cloned human gene and a panel of rodent-human somatic cell hybrids.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Hu01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Hu01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Hu01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Hu01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Hu01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Mu01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Mu01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Mu01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Mu01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Mu01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Ra01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Ra01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Ra01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Ra01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Ra01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Ca01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Ca01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Ca01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Ca01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Ca01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Po01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Po01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Po01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Po01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Po01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Bo01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Bo01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Bo01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Bo01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Bo01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Rb01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Rb01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Rb01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Rb01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Rb01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU077Mo01	Recombinant Tachykinin, Precursor 1 (TAC1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU077Mo01	Monoclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IP.
Antibodies	PAU077Mo01	Polyclonal Antibody to Tachykinin, Precursor 1 (TAC1)	WB; IHC; ICC; IF.
Assay Kits	CLU077Mo01	CLIA Kit for Tachykinin, Precursor 1 (TAC1)	CLIA assay for Antigen Detection
Assay Kits	ELU077Mo01	ELISA Kit for Tachykinin, Precursor 1 (TAC1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A."
FEBS Lett. 208:67-72(1986) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis."
Endocrinology 128:2441-2448(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour."
Eur. J. Biochem. 166:693-697(1987) [PubMed] [Europe PMC] [Abstract]

"Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes."
J. Neuroimmunol. 91:121-128(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of the C-terminal flanking peptide of human beta-preprotachykinin."
Peptides 11:907-910(1990) [PubMed] [Europe PMC] [Abstract]

"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles."
Biochemistry 45:2994-3004(2006) [PubMed] [Europe PMC] [Abstract]