Thyroid Hormone Responsive (THRSP)

S14; SPOT14; LPGP1; Lipogenic Protein 1; Thyroid hormone-inducible hepatic protein; Spot 14 protein

SPN	U067
HGNC	11800
MGI	109126
PubMed	19356628
RGD	3859
UniProt	Q92748
Wiki	THRSP

Thyroid hormone-inducible hepatic protein is a protein similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

Enhanced long-chain fatty acid synthesis may occur in breast cancer, where it is necessary for tumor growth and predicts a poor prognosis. The S14 protein functions to activate genes encoding the enzymes of fatty acid synthesis. Amplification of chromosome region 11q13, where the THRSP gene resides, also predicts a poor prognosis in breast tumors.

Reference

"Cloning and initial characterization of human and mouse Spot 14 genes."
FEBS Lett. 401:38-42(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human spot 14 protein interacts physically and functionally with the thyroid receptor."
Biochem. Biophys. Res. Commun. 357:133-138(2007) [PubMed] [Europe PMC] [Abstract]

"Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1."
Int. J. Biochem. Cell Biol. 40:1826-1834(2008) [PubMed] [Europe PMC] [Abstract]