Transmembrane Protease, Serine 2 (TMPRSS2)

PRSS10; Serine protease 10

SPN	U062
HGNC	11876
MGI	1354381
PubMed	18283340
RGD	620766
UniProt	O15393
Wiki	TMPRSS2

Transmembrane protease, serine 2 protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes.

This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reference

"Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3."
Genomics 44:309-320(1997) [PubMed] [Europe PMC] [Abstract]

"Mutation analyses of 268 candidate genes in human tumor cell lines."
Genomics 74:352-364(2001) [PubMed] [Europe PMC] [Abstract]

"Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia."
Cancer Res. 61:1686-1692(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues."
J. Pathol. 193:134-140(2001) [PubMed] [Europe PMC] [Abstract]

"TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells."
Am. J. Pathol. 176:2986-2996(2010) [PubMed] [Europe PMC] [Abstract]

"A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry."
J. Virol. 85:873-882(2011) [PubMed] [Europe PMC] [Abstract]

"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response."
J. Virol. 85:4122-4134(2011) [PubMed] [Europe PMC] [Abstract]

"TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium."
J. Virol. 87:6150-6160(2013) [PubMed] [Europe PMC] [Abstract]

"TMPRSS2 is an activating protease for respiratory parainfluenza viruses."
J. Virol. 87:11930-11935(2013) [PubMed] [Europe PMC] [Abstract]

"Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2."
J. Virol. 87:12552-12561(2013) [PubMed] [Europe PMC] [Abstract]

"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."
J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]

"An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."
Hum. Mutat. 29:130-141(2008) [PubMed] [Europe PMC] [Abstract]