Renalase (RNLS)
MAO-C; C10orf59; FAD-Dependent Amine Oxidase; Monoamine oxidase-C; alpha-NAD(P)H oxidase/anomerase
The renalase protein is an enzyme which breaks down catecholamines like adrenaline (epinephrine) and noradrenaline (norepinephrine) in the blood circulation. Researchers at Yale School of Medicine who discovered and named renalase in 2005 suggest that the human kidney releases this protein into the bloodstream to regulate blood pressure.
The renalase protein consists of a secretory signal peptide, a flavin adenine dinucleotide (FAD)-binding region, and an amine oxidase domain. At least four alternative splicing isoforms have been identified in humans (hRenalase1 to hRenalase4). Only hRenalase1 is detected in human blood samples, which means that hRenalase2 to 4 probably have a different function than hRenalase1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Hu01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Hu01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Hu01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Hu01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Hu01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Mu01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Mu01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Mu01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Mu01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Mu01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Ra01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Ra01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Ra01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Ra01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Ra01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Ca01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Ca01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Ca01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Ca01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Ca01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Po01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Po01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Po01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Po01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Po01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Bo01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Bo01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Bo01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Bo01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Bo01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Rb01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Rb01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Rb01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Rb01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Rb01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU012Mo01 | Recombinant Renalase (RNLS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU012Mo01 | Monoclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IP. |
| PAU012Mo01 | Polyclonal Antibody to Renalase (RNLS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU012Mo01 | CLIA Kit for Renalase (RNLS) | CLIA assay for Antigen Detection |
| ELU012Mo01 | ELISA Kit for Renalase (RNLS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure."
J. Clin. Invest. 115:1275-1280(2005) [PubMed] [Europe PMC] [Abstract]
"Renalase, a catecholamine-metabolising enzyme?"
J. Neural Transm. 114:775-776(2007) [PubMed] [Europe PMC] [Abstract]
"Renalase is an alpha-NAD(P)H oxidase/anomerase."
J. Am. Chem. Soc. 135:13980-13987(2013) [PubMed] [Europe PMC] [Abstract]
"FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation."
J. Mol. Biol. 411:463-473(2011) [PubMed] [Europe PMC] [Abstract]