Spermine Oxidase (SMOX)

SMO; PAO; PAOh1; C20orf16; Polyamine oxidase 1

SPN	U005
HGNC	15862
MGI	2445356
PubMed	17651718
RGD	1306049
UniProt	Q9NWM0
Wiki	SMOX

Spermine oxidase is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.

Reference

"Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure."
Cancer Res. 61:5370-5373(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics."
Biochem. J. 368:673-677(2002) [PubMed] [Europe PMC] [Abstract]

"Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology."
FEBS J. 275:2795-2806(2008) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Properties of purified recombinant human polyamine oxidase, PAOh1/SMO."
Biochem. Biophys. Res. Commun. 304:605-611(2003) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin."
Biochem. J. 367:665-675(2002) [PubMed] [Europe PMC] [Abstract]

"Catabolism of polyamines."
Amino Acids 26:217-233(2004) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]