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Smoothelin (SMTN)

SMSMO

Smoothelin is a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.
This gene, termed smoothelin (SMTN), encodes a 371-amino acid polypeptide. Sequence analysis revealed that the protein contains a 56-amino acid domain with significant homology to a sequence that flanks the actin-binding domains of dystrophin, utrophin, beta-spectrin, and alpha-actinin. Cell fractionation studies suggested to the authors that smoothelin is a part of the cytoskeleton.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Hu01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Hu01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Hu01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Hu01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Hu01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Mu01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Mu01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Mu01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Mu01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Mu01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Ra01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Ra01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Ra01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Ra01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Ra01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Ca01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Ca01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Ca01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Ca01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Ca01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Po01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Po01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Po01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Po01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Po01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Bo01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Bo01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Bo01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Bo01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Bo01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Rb01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Rb01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Rb01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Rb01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Rb01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU002Mo01 Recombinant Smoothelin (SMTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU002Mo01 Monoclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IP.
PAU002Mo01 Polyclonal Antibody to Smoothelin (SMTN) WB; IHC; ICC; IF.
Assay Kits CLU002Mo01 CLIA Kit for Smoothelin (SMTN) CLIA assay for Antigen Detection
ELU002Mo01 ELISA Kit for Smoothelin (SMTN) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells."
J. Cell Biol. 134:401-411(1996) [PubMed] [Europe PMC] [Abstract]

"A novel isoform of the smooth muscle cell differentiation marker smoothelin."
J. Mol. Med. 77:294-298(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of novel smoothelin isoforms in vascular smooth muscle."
J. Vasc. Res. 38:120-132(2001) [PubMed] [Europe PMC] [Abstract]

"Expression of the smoothelin gene is mediated by alternative promoters."
Cardiovasc. Res. 55:850-863(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]