Synaptosomal Associated Protein 23kDa (SNAP23)

SNAP23A; SNAP23B; Vesicle-membrane fusion protein SNAP-23

SPN	T999
HGNC	11131
MGI	109356
PubMed	11245593
RGD	620221
UniProt	O00161
Wiki	SNAP23

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25, form a complex which serves as a binding site for the general membrane fusion machinery.

Synaptosomal-associated protein 23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Reference

"Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues."
J. Biol. Chem. 271:13300-13303(1996) [PubMed] [Europe PMC] [Abstract]

"Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells."
Biochem. Biophys. Res. Commun. 231:808-812(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, chromosomal localization, alternative splicing, and isoforms of human Synaptosome associated protein-23 gene implicated in vesicle-membrane fusion."
Hum. Genet. 108:211-215(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]