Spindlin 1 (SPIN1)

SPN	T990
HGNC	11243
MGI	109242
PubMed	9053325
RGD	1306210
UniProt	Q9Y657
Wiki	SPIN1

Oh et al. (1997) cloned mouse Spin from a 2-cell stage embryo library and showed that it is homologous to the multicopy Ssty gene. In situ hybridization and RT-PCR assays detected murine Spin transcript in unfertilized eggs and 2-cell stage embryos, but not in 8-cell stage embryos.

Using differential display analysis of normal and cancerous ovarian tissues, followed by database analysis and PCR of total RNA from an ovarian cell line, Gao et al. (2005) cloned human SPIN. The 237-amino acid protein has a predicted molecular mass of 27 kD and shares 98% homology with mouse Spin. The C-terminal portion of SPIN was required for nuclear localization in transfected COS-7 cells.

Reference

"Cloning, characterization and mapping of human SPIN to human chromosome 9q22.1-22.3."
Chin. Sci. Bull. 45:909-914(2000)

"Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells."
Biochem. Biophys. Res. Commun. 335:343-350(2005) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes."
EMBO Rep. 12:1160-1166(2011) [PubMed] [Europe PMC] [Abstract]

"SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling."
Mol. Cancer Res. 10:326-335(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation."
J. Biol. Chem. 282:647-656(2007) [PubMed] [Europe PMC] [Abstract]

"Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1."
Proc. Natl. Acad. Sci. U.S.A. 109:17954-17959(2012) [PubMed] [Europe PMC] [Abstract]

"Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1."
Genes Dev. 28:622-636(2014) [PubMed] [Europe PMC] [Abstract]