Serotonin Transporter (SERT)

SLC6A4; SLC6-A4; HTT; 5-HTT; 5HTT; OCD1; hSERT; Solute Carrier Family 6,Member 4; Neurotransmitter Transporter,Serotonin; Sodium-dependent serotonin transporter

SPN	T967
HGNC	11050
MGI	96285
PubMed	20729489
RGD	3714
UniProt	P31645
Wiki	SERT

The serotonin transporter (SERT) is a monoamine transporter protein.This protein is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamine, cocaine, and MDMA, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Reference

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"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization."
Proc. Natl. Acad. Sci. U.S.A. 90:2542-2546(1993) [PubMed] [Europe PMC] [Abstract]

"Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter."
J. Neurochem. 60:2319-2322(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells."
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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter."
J. Biol. Chem. 281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract]

"Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2."
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"Plasma serotonin levels and the platelet serotonin transporter."
J. Neurochem. 102:206-215(2007) [PubMed] [Europe PMC] [Abstract]

"Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder."
J. Neurosci. 27:10878-10886(2007) [PubMed] [Europe PMC] [Abstract]

"Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter."
J. Biol. Chem. 283:9388-9398(2008) [PubMed] [Europe PMC] [Abstract]

"The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network."
PLoS ONE 4:E4730-E4730(2009) [PubMed] [Europe PMC] [Abstract]

"Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function."
Mol. Pharmacol. 81:73-85(2012) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype."
Mol. Psychiatry 8:933-936(2003) [PubMed] [Europe PMC] [Abstract]

"A human serotonin transporter mutation causes constitutive activation of transport activity."
Mol. Pharmacol. 64:440-446(2003) [PubMed] [Europe PMC] [Abstract]

"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene."
Science 301:386-389(2003) [PubMed] [Europe PMC] [Abstract]

"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence."
Am. J. Med. Genet. B Neuropsychiatr. Genet. 133:79-84(2005) [PubMed] [Europe PMC] [Abstract]