Sortilin 1 (SORT1)

NT3; Gp95; NTR3; 100 kDa NT receptor; Glycoprotein 95; Neurotensin receptor 3

SPN	T962
HGNC	11186
MGI	1338015
PubMed	20816088
RGD	619999
UniProt	Q99523
Wiki	Sortilin_1

Sortilin is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA proteins.

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor."
J. Biol. Chem. 273:26273-26276(1998) [PubMed] [Europe PMC] [Abstract]

"Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding."
EMBO J. 18:595-604(1999) [PubMed] [Europe PMC] [Abstract]

"The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin."
FEBS Lett. 429:27-30(1998) [PubMed] [Europe PMC] [Abstract]

"Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase."
J. Biol. Chem. 274:8832-8836(1999) [PubMed] [Europe PMC] [Abstract]

"The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein."
EMBO J. 20:2180-2190(2001) [PubMed] [Europe PMC] [Abstract]

"Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."
J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]

"Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line."
Biochem. Biophys. Res. Commun. 298:760-764(2002) [PubMed] [Europe PMC] [Abstract]

"Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization."
J. Cell. Physiol. 193:73-79(2002) [PubMed] [Europe PMC] [Abstract]

"Structural basis for recognition of acidic-cluster dileucine sequence by GGA1."
Nature 415:937-941(2002) [PubMed] [Europe PMC] [Abstract]

"The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin."
EMBO J. 22:6430-6437(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
EMBO J. 23:1680-1680(2004)

"Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia."
J. Neurosci. 23:1198-1205(2003) [PubMed] [Europe PMC] [Abstract]

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Int. J. Biochem. Cell Biol. 36:2153-2168(2004) [PubMed] [Europe PMC] [Abstract]

"Functional organization of the sortilin Vps10p domain."
J. Biol. Chem. 279:50221-50229(2004) [PubMed] [Europe PMC] [Abstract]

"Sortilin is essential for proNGF-induced neuronal cell death."
Nature 427:843-848(2004) [PubMed] [Europe PMC] [Abstract]

"ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin."
J. Neurosci. 25:5455-5463(2005) [PubMed] [Europe PMC] [Abstract]

"Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway."
J. Neurosci. 25:6156-6166(2005) [PubMed] [Europe PMC] [Abstract]

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
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Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]

"Biological, clinical and population relevance of 95 loci for blood lipids."
Nature 466:707-713(2010) [PubMed] [Europe PMC] [Abstract]

"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus."
Nature 466:714-719(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling."
Nat. Neurosci. 14:54-61(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain."
Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract]