Dermcidin (DCD)

HCAP; AIDD; DCD1; DSEP; PIF; Proteolysis Inducing Factor; Preproteolysin; Diffusible Survival/Evasion Peptide; Survival Promoting Peptide

SPN	T961
HGNC	14669
PubMed	11694882
UniProt	P81605
Wiki	Dermcidin

Dermcidin is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.

High performance liquid chromatography, mass spectrometry, and microsequence analysis of sweat showed a processed 47-amino acid DCD peptide with a calculated mass of 4.7 kD, compared with the expected 9.3 kD of full-length DCD without the signal peptide.DCD expression in skin, melanocytic nevus, and cutaneous melanoma tissue, but not in any other organ systems tested.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Hu01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Hu01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Hu01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Hu01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Hu01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Mu01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Mu01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Mu01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Mu01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Mu01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Ra01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Ra01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Ra01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Ra01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Ra01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Ca01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Ca01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Ca01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Ca01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Ca01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Po01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Po01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Po01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Po01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Po01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Bo01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Bo01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Bo01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Bo01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Bo01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Rb01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Rb01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Rb01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Rb01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Rb01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT961Mo01	Recombinant Dermcidin (DCD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT961Mo01	Monoclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IP.
Antibodies	PAT961Mo01	Polyclonal Antibody to Dermcidin (DCD)	WB; IHC; ICC; IF.
Assay Kits	CLT961Mo01	CLIA Kit for Dermcidin (DCD)	CLIA assay for Antigen Detection
Assay Kits	ELT961Mo01	ELISA Kit for Dermcidin (DCD)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Dermcidin: a novel human antibiotic peptide secreted by sweat glands."
Nat. Immunol. 2:1133-1137(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity."
Biochem. Biophys. Res. Commun. 357:828-833(2007) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006)

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin."
J. Neurosci. 18:7047-7060(1998) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles."
BMB Rep. 43:362-368(2010) [PubMed] [Europe PMC] [Abstract]