Death Inducer Obliterator 1 (DIDO1)

BYE1; DATF1; DIDO2; DIDO3; DIO1; Death Associated Transcription Factor 1

SPN	T956
HGNC	2680
MGI	1344352
PubMed	22469980
RGD	1311173
UniProt	Q9BTC0
Wiki	DIDO1

Death-inducer obliterator 1 is a protein encoded by the DIDO1 gene.Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals.

In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.

Reference

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