Defensin Beta 2 (DEFb2)
B-DF2; DEFB2; BD2; DEF-B2; HBD2; DEFB102; HBD-2; SAP1; DEFB4A; DEFB4; Skin-Antimicrobial Peptide 1
Beta-defensin 2 is a protein encoded by the DEFB4 gene.Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. Every mammalian species explored thus far has beta-defensins. In cows, as many as 13 beta-defensins exist in neutrophils. However, in other species, beta-defensins are more often produced by epithelial cells lining various organs. Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and degranulation of mast cells, resulting in the release of histamine and prostaglandin D2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Hu01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Hu01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Hu01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Hu01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Hu01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Mu01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Mu01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Mu01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Mu01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Mu01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Ra01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Ra01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Ra01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Ra01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Ra01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Ca01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Ca01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Ca01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Ca01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Ca01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Po01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Po01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Po01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Po01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Po01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Bo01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Bo01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Bo01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Bo01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Bo01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Rb01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Rb01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Rb01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Rb01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Rb01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT951Mo01 | Recombinant Defensin Beta 2 (DEFb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT951Mo01 | Monoclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IP. |
| PAT951Mo01 | Polyclonal Antibody to Defensin Beta 2 (DEFb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT951Mo01 | CLIA Kit for Defensin Beta 2 (DEFb2) | CLIA assay for Antigen Detection |
| ELT951Mo01 | ELISA Kit for Defensin Beta 2 (DEFb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A peptide antibiotic from human skin."
Nature 387:861-861(1997) [PubMed] [Europe PMC] [Abstract]
"Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation."
Gene 222:237-244(1998) [PubMed] [Europe PMC] [Abstract]
"Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells."
Infect. Immun. 68:113-119(2000) [PubMed] [Europe PMC] [Abstract]
"Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia."
Am. J. Respir. Cell Mol. Biol. 22:714-721(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Chemical synthesis of beta-defensins and LEAP-1/hepcidin."
J. Pept. Res. 59:241-248(2002) [PubMed] [Europe PMC] [Abstract]
"The structure of human beta-defensin-2 shows evidence of higher order oligomerization."
J. Biol. Chem. 275:32911-32918(2000) [PubMed] [Europe PMC] [Abstract]
"Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity."
Protein Sci. 10:2470-2479(2001) [PubMed] [Europe PMC] [Abstract]