Non Catalytic Region Of Tyrosine Kinase Adaptor Protein 1 (NCK1)

NCKalpha; NCKa; NCK adaptor protein 1; Cytoplasmic protein NCK1; SH2/SH3 adaptor protein NCK-alpha

SPN	T949
HGNC	7664
MGI	109601
PubMed	23280595
RGD	1310688
UniProt	P16333
Wiki	NCK1

The Cytoplasmic protein NCK1 Protein belongs to the adaptor family of proteins.The Nck family has two known members in human cells.(Nck-1/Nckalpha and NcK2/NcKbeta), two in mouse cells(mNckalpha and mNckbeta/Grb4) and one in drosophila( Dock means dreadlocks-ortholog). The two murine gene products exhibits 68% aminoacid identity to one another,with most of the sequence variation being located to the linker regions between the SH3 and SH2 domains, and are 96% identical to their human counterparts. While human nck-1 gene has been localised to the 3q21 locus of chromosome 3,the nck-2 genecan be found on chromosome 2 at the 2q12 locus. The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains.

Reference

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Submitted (NOV-2005) to the PDB data bank

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