Phenol Sulfotransferase (PST)

SULT1A1; HAST1/HAST2; ST1A3; STP1; TSPST1; Sulfotransferase 1A1; Aryl sulfotransferase 1; Phenol sulfotransferase 1; Thermostable phenol sulfotransferase

SPN	T944
HGNC	11453
MGI	102896
PubMed	2873064
RGD	3767
UniProt	P50225
Wiki	SULT1A1

Phenol sulfotransferase, or PST (EC 2.8.2.1), catalyzes the sulfate conjugation of catecholamines and of phenolic drugs. PST is widely distributed in human and animal tissues that include the blood platelets. Human platelet PST exists in at least a thermolabile, or monoamine-metabolizing (SULT1A3, or STM), form and a thermostable, or phenol-metabolizing, form. Evidence that inheritance contributes to differences in levels of the 2 forms of the enzyme in whites was presented by Reveley et al. (1982), Price et al. (1988), and Van Loon and Weinshilboum (1984). Anderson and Jackson (1984) showed that the mean basal level of platelet thermostable PST activity in American blacks is significantly higher than the mean basal level in whites, whereas the average platelet thermolabile PST activity does not differ significantly in the 2 groups.

Reference

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Biochem. Biophys. Res. Commun. 195:120-127(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular characterisation of a human aryl sulfotransferase cDNA."
Biochem. Biophys. Res. Commun. 192:671-676(1993) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase."
Mol. Pharmacol. 43:70-77(1993) [PubMed] [Europe PMC] [Abstract]

"Structural similarity and diversity of sulfotransferases."
Chem. Biol. Interact. 92:107-117(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus."
Biochem. Biophys. Res. Commun. 207:701-707(1995) [PubMed] [Europe PMC] [Abstract]

"Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form."
Biochem. Biophys. Res. Commun. 208:855-862(1995) [PubMed] [Europe PMC] [Abstract]

"Primary structures and properties of two related forms of aryl sulfotransferases in human liver."
Pharmacogenetics 5:S135-S140(1995) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16."
Biochem. Biophys. Res. Commun. 228:134-140(1996) [PubMed] [Europe PMC] [Abstract]

"Human phenol sulfotransferase gene contains two alternative promoters: structure and expression of the gene."
DNA Cell Biol. 15:367-375(1996) [PubMed] [Europe PMC] [Abstract]

"A single amino acid, Glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3."
Mol. Pharmacol. 54:942-948(1998) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7."
Genomics 18:440-443(1993) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies."
Biochem. J. 302:497-502(1994) [PubMed] [Europe PMC] [Abstract]

"Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability."
Chem. Biol. Interact. 92:57-66(1994) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition."
J. Biol. Chem. 278:7655-7662(2003) [PubMed] [Europe PMC] [Abstract]

"The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates."
J. Biol. Chem. 280:41482-41486(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2."
Biochem. Biophys. Res. Commun. 396:429-434(2010) [PubMed] [Europe PMC] [Abstract]

"Directed evolution of sulfotransferases and paraoxonases by ancestral libraries."
J. Mol. Biol. 411:837-853(2011) [PubMed] [Europe PMC] [Abstract]

"The molecular basis for the broad substrate specificity of human sulfotransferase 1A1."
PLoS ONE 6:E26794-E26794(2011) [PubMed] [Europe PMC] [Abstract]

"Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype."
Biochem. Biophys. Res. Commun. 239:298-304(1997) [PubMed] [Europe PMC] [Abstract]

"Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2."
Pharmacogenetics 10:163-169(2000) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]