Guanylate Binding Protein 4 (GBP4)

GTP-binding protein 4; Guanine nucleotide-binding protein 4

SPN	T934
HGNC	20480
MGI	1926263
PubMed	22095711
RGD	1310579
UniProt	Q96PP9

Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP.Vestal (2005) reported that the 642-amino acid GBP4 protein shares 50 to 55% identity with GBP1 , GBP2 , and GBP5 . GBP4 contains a GTP-binding domain, but it lacks a C-terminal CaaX isoprenylation motif found in the other 3 GBPs.

Olszewski et al. (2006) found that GBP4 shares 74% and 81% amino acid identity with GBP6 and GBP7 , respectively. All GBPs, including GBP4, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP4 has a unique 15-amino acid group at its N terminus that is not found in other GBPs.

Reference

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Unique features of different members of the human guanylate-binding protein family."
J. Interferon Cytokine Res. 27:44-52(2007) [PubMed] [Europe PMC] [Abstract]