S100 Calcium Binding Protein (S100)

S100-A1; S100A1; S100-Alpha; S-100 Protein; S-100 protein subunit alpha; S-100 protein alpha chain

SPN	T924
HGNC	10486
MGI	1338917
PubMed	15578088
RGD	3614
UniProt	P23297
Wiki	S100A1

A1is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. This protein may function in stimulation of Ca²⁺-induced Ca²⁺ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation.

Reduced expression of this protein has been implicated in cardiomyopathies. S100A1 overexpression enhances cardiac contractile performance which suggests that S100A1 is a regulator of myocardial contractility. S100A1 improves cardiac performance both by regulating calcium ion handling by the sarcoplasmic reticulum and the responsiveness of myofibrils to calcium ion.

Reference

"S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart."
Biochemistry 31:10258-10264(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."
J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]

"Heterodimeric interaction and interfaces of S100A1 and S100P."
Biochem. J. 382:375-383(2004) [PubMed] [Europe PMC] [Abstract]

"S100A1 and calmodulin compete for the same binding site on ryanodine receptor."
J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]

"S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats."
FEBS Lett. 584:1119-1125(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."
J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]

"Solution NMR structure and dynamics of human apo-S100A1 protein."
J. Struct. Biol. 174:391-399(2011) [PubMed] [Europe PMC] [Abstract]

"Post-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein."
J. Biol. Chem. 287:40457-40470(2012) [PubMed] [Europe PMC] [Abstract]