Prokineticin Receptor 2 (PKR2)

PROKR2; KAL3; GPR73L1; GPR73b; GPRg2; G Protein-Coupled receptor 73-Like 1

SPN	T922
HGNC	15836
MGI	2181363
PubMed	17202262
RGD	708445
UniProt	Q8NFJ6
Wiki	PKR2

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.

Lin et al. (2002) cloned human GPR73L1 (PROKR2) by PCR of a pooled testis and fetal brain cDNA library. They also cloned GPR73 (PROKR1), which shares 85% overall sequence identity with GPR73L1. The greatest divergence between the proteins is in the N terminus, and both share about 80% sequence identity with mouse Gpr73. RT-PCR detected expression of GPR73L1 in brain, testis, small intestine, ovary, thyroid, pituitary, and salivary gland.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Hu01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Hu01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Hu01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Hu01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Hu01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Mu01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Mu01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Mu01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Mu01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Mu01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Ra01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Ra01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Ra01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Ra01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Ra01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Ca01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Ca01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Ca01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Ca01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Ca01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Po01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Po01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Po01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Po01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Po01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Bo01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Bo01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Bo01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Bo01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Bo01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Rb01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Rb01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Rb01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Rb01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Rb01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT922Mo01	Recombinant Prokineticin Receptor 2 (PKR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT922Mo01	Monoclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IP.
Antibodies	PAT922Mo01	Polyclonal Antibody to Prokineticin Receptor 2 (PKR2)	WB; IHC; ICC; IF.
Assay Kits	CLT922Mo01	CLIA Kit for Prokineticin Receptor 2 (PKR2)	CLIA assay for Antigen Detection
Assay Kits	ELT922Mo01	ELISA Kit for Prokineticin Receptor 2 (PKR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."
J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of prokineticin receptors."
Biochim. Biophys. Acta 1579:173-179(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Evidence that prokineticin receptor 2 exists as a dimer in vivo."
Cell. Mol. Life Sci. 68:2919-2929(2011) [PubMed] [Europe PMC] [Abstract]

"Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2."
PLoS Genet. 2:1648-1652(2006) [PubMed] [Europe PMC] [Abstract]

"Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum."
J. Clin. Endocrinol. Metab. 93:3551-3559(2008) [PubMed] [Europe PMC] [Abstract]

"PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity."
Hum. Mol. Genet. 18:75-81(2009) [PubMed] [Europe PMC] [Abstract]

"SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome."
PLoS Genet. 8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]

"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]

"The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients."
J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]