Fibroblast Growth Factor 8, Androgen Induced (FGF8)

AIGF; HBGF8; Androgen-induced growth factor; Heparin-binding growth factor 8

SPN	T919
HGNC	3686
MGI	99604
PubMed	9609821
RGD	70891
UniProt	P55075
Wiki	FGF8

Fibroblast growth factor 8 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. The alternative splicing of this gene results in four transcript variants.

Reference

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