Platelet Derived Growth Factor D (PDGFD)

PDGF-D; IEGF; SCDGF-B; Spinal Cord Derived Growth Factor B; Iris-expressed growth factor; Platelet-derived growth factor D, receptor-binding form/latent form

SPN	T908
HGNC	30620
MGI	1919035
PubMed	11331882
RGD	621880
UniProt	Q9GZP0
Wiki	PDGFD

Platelet-derived growth factor D is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor.

This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.

Reference

"Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein."
Biochem. Biophys. Res. Commun. 280:733-737(2001) [PubMed] [Europe PMC] [Abstract]

"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor."
Nat. Cell Biol. 3:512-516(2001) [PubMed] [Europe PMC] [Abstract]

"PDGF D, a novel protease-activated growth factor."
Nat. Cell Biol. 3:517-521(2001) [PubMed] [Europe PMC] [Abstract]

"Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium."
Mol. Vis. 8:185-195(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor-D expression in developing and mature human kidneys."
Kidney Int. 62:2043-2054(2002) [PubMed] [Europe PMC] [Abstract]

"Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes."
Circulation 103:2242-2247(2001) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer."
Cancer Res. 62:2468-2473(2002) [PubMed] [Europe PMC] [Abstract]

"Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury."
J. Am. Soc. Nephrol. 14:2544-2555(2003) [PubMed] [Europe PMC] [Abstract]

"PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis."
Blood 104:3198-3204(2004) [PubMed] [Europe PMC] [Abstract]

"Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family."
FEBS J. 272:5723-5741(2005) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells."
Mol. Cell. Biol. 25:6279-6288(2005) [PubMed] [Europe PMC] [Abstract]

"Emerging roles of PDGF-D signaling pathway in tumor development and progression."
Biochim. Biophys. Acta 1806:122-130(2010) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]