Platelet Derived Growth Factor Receptor Like Protein (PDGFRL)

PRLTS; PDGF-Receptor Beta-Like Tumor Suppressor

SPN	T905
HGNC	8805
MGI	1916047
PubMed	22926996
RGD	1308028
UniProt	Q15198

PDGFRL is a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.

The 375-amino acid protein predicted from this cDNA has hydrophobic sequence at the NH2 terminus, characteristic of signal peptides. It shows 27% and 25% identity with the extracellular domain of platelet-derived growth factor receptor-beta and FMS-like tyrosine kinase (FLT), respectively.

Reference

"Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene."
Oncogene 10:891-895(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."
J. Biol. Chem. 284:34954-34963(2009) [PubMed] [Europe PMC] [Abstract]

"Genetic variant on PDGFRL associated with Behcet disease in Chinese Han populations."
Hum. Mutat. 34:74-78(2013) [PubMed] [Europe PMC] [Abstract]