Adrenergic Receptor Beta 1 (ADRb1)

ADR-B1; ADRB1R; B1AR; BETA1AR; RHR; Beta 1 Adrenoreceptor; Beta-1 adrenoceptor

SPN	T903
HGNC	285
MGI	87937
PubMed	23114278
RGD	2059
UniProt	P08588
Wiki	ADRB1

The beta-1 adrenergic receptoris a beta-adrenergic receptor,The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially noradrenaline (norepinephrine) and adrenaline (epinephrine). Although dopamine is a catecholamine, its receptors are in a different category.

Many cells possess these receptors, and the binding of an agonist will generally cause a sympathetic response (i.e. the fight-or-flight response). For instance, the heart rate will increase and the pupils will dilate, energy will be mobilized, and blood flow diverted from other non-essential organs to skeletal muscle.Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins.

Reference

"Cloning of the cDNA for the human beta 1-adrenergic receptor."
Proc. Natl. Acad. Sci. U.S.A. 84:7920-7924(1987) [PubMed] [Europe PMC] [Abstract]

"Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C."
Hum. Mutat. 14:271-271(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation."
Mol. Cell. Biol. 22:7942-7952(2002) [PubMed] [Europe PMC] [Abstract]

"Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression."
J. Biol. Chem. 279:50190-50196(2004) [PubMed] [Europe PMC] [Abstract]

"Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway."
J. Biol. Chem. 286:22441-22455(2011) [PubMed] [Europe PMC] [Abstract]

"A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor."
J. Biol. Chem. 274:12670-12674(1999) [PubMed] [Europe PMC] [Abstract]

"A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure."
Eur. Heart J. 21:1853-1858(2000) [PubMed] [Europe PMC] [Abstract]

"A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate."
Am. J. Hum. Genet. 70:935-942(2002) [PubMed] [Europe PMC] [Abstract]