Sphingosine 1 Phosphate Receptor 1 (S1PR1)

CD363; EDG1; S1-PR1; S1P1; ECGF1; CHEDG1; Endothelial differentiation G-protein coupled receptor 1; Sphingolipid G-Protein-Coupled Receptor 1

SPN	T890
HGNC	3165
MGI	1096355
PubMed	23969695
RGD	61958
UniProt	P21453
Wiki	S1PR1

S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P₁ and EDG1 (endothelial differentiation gene 1) is a protein encoded by the S1PR1 gene. S1PR1 encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

The protein is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

Reference

"An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors."
J. Biol. Chem. 265:9308-9313(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids."
FEBS Lett. 417:279-282(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate."
J. Biol. Chem. 275:39379-39384(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway."
J. Biol. Chem. 271:11272-11279(1996) [PubMed] [Europe PMC] [Abstract]

"Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1."
Science 279:1552-1555(1998) [PubMed] [Europe PMC] [Abstract]

"Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5."
J. Biol. Chem. 274:18997-19002(1999) [PubMed] [Europe PMC] [Abstract]

"A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors."
J. Biol. Chem. 276:49213-49220(2001) [PubMed] [Europe PMC] [Abstract]

"Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis."
Mol. Cell 8:693-704(2001) [PubMed] [Europe PMC] [Abstract]

"Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility."
Science 291:1800-1803(2001) [PubMed] [Europe PMC] [Abstract]

"Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells."
Glycoconj. J. 21:497-501(2004) [PubMed] [Europe PMC] [Abstract]

"Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids."
Circ. Res. 104:978-986(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a lipid G protein-coupled receptor."
Science 335:851-855(2012) [PubMed] [Europe PMC] [Abstract]