Melatonin Receptor 1A (MTNR1A)

MT1; MEL-1A-R

SPN	T884
HGNC	7463
MGI	102967
PubMed	21211471
RGD	620797
UniProt	P48039
Wiki	MTNR1A

Melatonin receptor type 1A is one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length.

The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Reference

"Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses."
Neuron 13:1177-1185(1994) [PubMed] [Europe PMC] [Abstract]

"Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders."
Biochem. Biophys. Res. Commun. 262:832-837(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]