Insulin Like Growth Factor Binding Protein 7 (IGFBP7)

FSTL2; IGFBP-7v; MAC25; PSF; TAF; IGFBP-rP1; MAC25 protein; Prostacyclin-stimulating factor; PGI2-stimulating factor; Tumor-derived adhesion factor

SPN	T873
HGNC	5476
MGI	1352480
PubMed	21328580
RGD	1306201
UniProt	Q16270
Wiki	IGFBP7

By Northern blot analysis, Oh et al. (1996) found that mac25, or IGFBP7, wajs expressed as a 1.1-kb transcript in a broad spectrum of normal tissues. These authors reported that the predicted 277-amino acid protein contains a 26-amino acid signal sequence and the IGFBP motif (GCGCCXXC) at the N terminus. The IGFBP motif is located in a region containing a cluster of 12 conserved cysteines, of which 11 are found in IGFBP7.

The amino acid sequences of IGFBP7 and IGFBPs share 20 to 25% identity. Oh et al. (1996) found that recombinant IGFBP7 specifically bound IGFs, although with relatively low affinity. Kim et al. (1997) proposed that IGFBP7, CTGF , NOV , and IGFBP10 constitute a subfamily of low-affinity IGFBPs.

Reference

"Identification and characterization of genes differentially expressed in meningiomas."
Cell Growth Differ. 4:715-722(1993) [PubMed] [Europe PMC] [Abstract]

"Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells."
Biochem. J. 303:591-598(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells."
Biochem. Biophys. Res. Commun. 198:1046-1053(1994) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II."
J. Biol. Chem. 271:30322-30325(1996) [PubMed] [Europe PMC] [Abstract]

"Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells."
J. Clin. Endocrinol. Metab. 86:4504-4511(2001) [PubMed] [Europe PMC] [Abstract]

"Screening of human SNP database identifies recoding sites of A-to-I RNA editing."
RNA 14:2074-2085(2008) [PubMed] [Europe PMC] [Abstract]

"Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms."
Am. J. Hum. Genet. 89:313-319(2011) [PubMed] [Europe PMC] [Abstract]