Calpain 5 (CAPN5)

HTRA3; nCL3; Calpain htra-3; New calpain 3

SPN	T851
HGNC	1482
MGI	1100859
PubMed	14749380
RGD	620084
UniProt	O15484
Wiki	CAPN5

CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.

Expression was observed in embryonic and newborn thymi, in various epithelial tissues, and in tissues of the central nervous system. In the thymus, Capn5 was expressed mainly in immature Cd25-positive embryonic thymocytes. Despite the widespread expression, most homozygous Capn5-null mice were viable and fertile and appeared healthy. Histopathologic analysis revealed no differences between Capn5-null and wildtype mice.

Reference

"Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene."
Biochem. Biophys. Res. Commun. 239:845-850(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
Genomics 45:175-184(1997) [PubMed] [Europe PMC] [Abstract]

"Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration."
PLoS Genet. 8:E1003001-E1003001(2012) [PubMed] [Europe PMC] [Abstract]