Calpain 9 (CAPN9)

GC36; nCL4; Novel Calpain Large Subunit-4; Digestive tract-specific calpain; New calpain 4

SPN	T850
HGNC	1486
MGI	1920897
PubMed	15665521
RGD	70965
UniProt	O14815
Wiki	CAPN9

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress.

Calpain-9 is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Hu01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Hu01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Hu01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Hu01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Hu01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Mu01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Mu01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Mu01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Mu01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Mu01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Ra01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Ra01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Ra01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Ra01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Ra01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Ca01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Ca01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Ca01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Ca01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Ca01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Po01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Po01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Po01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Po01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Po01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Bo01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Bo01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Bo01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Bo01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Bo01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Rb01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Rb01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Rb01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Rb01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Rb01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT850Mo01	Recombinant Calpain 9 (CAPN9)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT850Mo01	Monoclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IP.
Antibodies	PAT850Mo01	Polyclonal Antibody to Calpain 9 (CAPN9)	WB; IHC; ICC; IF.
Assay Kits	CLT850Mo01	CLIA Kit for Calpain 9 (CAPN9)	CLIA assay for Antigen Detection
Assay Kits	ELT850Mo01	ELISA Kit for Calpain 9 (CAPN9)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract."
Biol. Chem. 379:175-183(1998) [PubMed] [Europe PMC] [Abstract]

"Isolation of two novel genes, down-regulated in gastric cancer."
Jpn. J. Cancer Res. 91:459-463(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition."
J. Mol. Biol. 366:216-229(2007) [PubMed] [Europe PMC] [Abstract]