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Calpain 10 (CAPN10)

Calcium-activated neutral proteinase 10

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits.
This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. Calpain-10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Hu01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Hu01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Hu01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Hu01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Hu01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Mu01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Mu01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Mu01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Mu01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Mu01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Ra01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Ra01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Ra01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Ra01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Ra01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Ca01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Ca01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Ca01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Ca01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Ca01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Po01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Po01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Po01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Po01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Po01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Bo01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Bo01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Bo01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Bo01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Bo01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Rb01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Rb01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Rb01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Rb01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Rb01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT849Mo01 Recombinant Calpain 10 (CAPN10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT849Mo01 Monoclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IP.
PAT849Mo01 Polyclonal Antibody to Calpain 10 (CAPN10) WB; IHC; ICC; IF.
Assay Kits CLT849Mo01 CLIA Kit for Calpain 10 (CAPN10) CLIA assay for Antigen Detection
ELT849Mo01 ELISA Kit for Calpain 10 (CAPN10) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus."
Nat. Genet. 26:163-175(2000) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 26:502-502(2000)

"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes."
J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract]

"Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells."
Mol. Genet. Metab. 91:318-324(2007) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]