Cathepsin F (CTSF)

CTS-F; CATSF

SPN	T846
HGNC	2531
MGI	1861434
PubMed	16508006
RGD	1308181
UniProt	Q9UBX1
Wiki	Cathepsin_F

The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously

Reference

"Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain."
J. Biol. Chem. 274:13800-13809(1999) [PubMed] [Europe PMC] [Abstract]

"Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen."
Biochem. Biophys. Res. Commun. 257:313-318(1999) [PubMed] [Europe PMC] [Abstract]

"The human cathepsin F gene -- a fusion product between an ancestral cathepsin and cystatin gene."
Biol. Chem. 380:1439-1442(1999) [PubMed] [Europe PMC] [Abstract]

"Human cathepsins F and W: a new subgroup of cathepsins."
Biochem. Biophys. Res. Commun. 259:401-407(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization."
J. Biol. Chem. 273:32000-32008(1998) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators."
J. Mol. Biol. 322:559-568(2002) [PubMed] [Europe PMC] [Abstract]

"Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis."
Hum. Mol. Genet. 22:1417-1423(2013) [PubMed] [Europe PMC] [Abstract]