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Cathepsin H (CTSH)

CTS-H; CPSB; ACC4; ACC5; Minichain; Pro-cathepsin H

Cathepsin H is is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor.
The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.Two transcript variants encoding different isoforms have been found for this gene.One form of Batten disease, representing perhaps about one-fourth of all cases, has been found to show deficiency of cathepsin H. The Batten disease phenotype maps to chromosome 16, however.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Hu01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Hu01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Hu01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Hu01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Hu01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Mu01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Mu01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Mu01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Mu01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Mu01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Ra01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Ra01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Ra01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Ra01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Ra01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Ca01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Ca01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Ca01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Ca01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Ca01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Po01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Po01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Po01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Po01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Po01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Bo01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Bo01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Bo01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Bo01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Bo01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Rb01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Rb01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Rb01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Rb01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Rb01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT845Mo01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT845Mo01 Monoclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
PAT845Mo01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IF.
Assay Kits CLT845Mo01 CLIA Kit for Cathepsin H (CTSH) CLIA assay for Antigen Detection
ELT845Mo01 ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase."
Nucleic Acids Res. 17:9471-9471(1989) [PubMed] [Europe PMC] [Abstract]

"Analysis of a truncated form of cathepsin H in human prostate tumor cells."
J. Biol. Chem. 277:11533-11538(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H."
Biol. Chem. Hoppe-Seyler 369:469-475(1988) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequences of the human kidney cathepsins H and L."
FEBS Lett. 228:341-345(1988) [PubMed] [Europe PMC] [Abstract]

"Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens."
(In) Turk V. (eds.);Cysteine proteinases and their inhibitors, pp.3-18, Walter de Gruyter, Berlin and New York (1986)

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]