Cathepsin Z (CTSZ)

CTS-Z; CTSX; Cathepsin P; Cathepsin X

SPN	T843
HGNC	2547
MGI	1891190
PubMed	14990313
UniProt	Q9UBR2
Wiki	Cathepsin_Z

Cathepsin Z or cathepsin X is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. The predicted 303-amino acid protein has the domain structure characteristic of cysteine proteinases, including a signal sequence, a prodomain, and a catalytic domain responsible for proteolytic activity. However, it also contains 3 unique peptide insertions. Cathepsin Z shares protein sequence identity with other human cysteine proteinases of the papain family, including 34% with cathepsin C and 26% with cathepsin B.

Reference

"Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions."
FEBS Lett. 434:135-139(1998) [PubMed] [Europe PMC] [Abstract]

"Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location."
J. Biol. Chem. 273:16816-16823(1998) [PubMed] [Europe PMC] [Abstract]

"Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization."
Biochim. Biophys. Acta 1491:93-106(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family."
Pflugers Arch. 439:R116-R118(2000) [PubMed] [Europe PMC] [Abstract]

"Human cathepsin X: a cysteine protease with unique carboxypeptidase activity."
Biochemistry 38:12648-12654(1999) [PubMed] [Europe PMC] [Abstract]

"Tissue expression and immunolocalization of a novel human cathepsin P."
Pflugers Arch. 439:R119-R121(2000) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease."
Structure 8:305-313(2000) [PubMed] [Europe PMC] [Abstract]