Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP)

NOS1-AP; CAPON; Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein

SPN	T828
HGNC	16859
MGI	1917979
PubMed	18474209
RGD	620106
UniProt	O75052
Wiki	NOS1AP

NOS1AP encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. NOS1AP polymorphisms has been associated with the QT interval length. CAPON appears to have 2 alternate splice forms, one encoding a 125-amino acid protein and the other encoding a 327-amino acid protein. The 125-amino acid C-terminal fragment of CAPON specifically interacted with NOS1 in a 2-hybrid system.

Reference

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DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]

"Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder."
PLoS Med. 2:E263-E263(2005) [PubMed] [Europe PMC] [Abstract]

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95."
Neuron 20:115-124(1998) [PubMed] [Europe PMC] [Abstract]

"A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization."
Nat. Genet. 38:644-651(2006) [PubMed] [Europe PMC] [Abstract]

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Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]