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Galectin 2 (GAL2)

LGALS2; HL14; Lectin,Galactoside-Binding Soluble 2; Beta-galactoside-binding lectin L-14-II; Lactose-binding lectin 2; S-Lac lectin 2

The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion.Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Galectin-2, a lectin binding to ß-galactoside, was found to trigger apoptosis of activated T cells and leaves naive or memory T cells unaltered. Cytokine secretion of activated T cells was significantly shifted to the Th2 profile. In vivo experiments showed a significant decrease of bowel inflammation during the course of several days in galectin-2 treated mice featuring DSS-colitis. Furthermore, contact hypersensitivity (CHS) responses were reduced significantly in Galectin-2 treated mice after sensitization to contact allergens.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Hu01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Hu01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Hu01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Hu01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Hu01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Mu01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Mu01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Mu01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Mu01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Mu01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Ra01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Ra01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Ra01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Ra01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Ra01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Ca01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Ca01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Ca01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Ca01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Ca01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Po01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Po01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Po01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Po01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Po01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Bo01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Bo01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Bo01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Bo01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Bo01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Rb01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Rb01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Rb01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Rb01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Rb01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT818Mo01 Recombinant Galectin 2 (GAL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT818Mo01 Monoclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IP.
PAT818Mo01 Polyclonal Antibody to Galectin 2 (GAL2) WB; IHC; ICC; IF.
Assay Kits CLT818Mo01 CLIA Kit for Galectin 2 (GAL2) CLIA assay for Antigen Detection
ELT818Mo01 ELISA Kit for Galectin 2 (GAL2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin."
J. Biol. Chem. 267:10601-10606(1992) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Genomic sequence and organization of two members of a human lectin gene family."
Biochemistry 30:82-89(1991) [PubMed] [Europe PMC] [Abstract]

"Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes."
Proc. Natl. Acad. Sci. U.S.A. 83:7603-7607(1986) [PubMed] [Europe PMC] [Abstract]

"X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution."
J. Biol. Chem. 268:27034-27038(1993) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]