Galectin 3 (GAL3)

LGALS3; CBP35; GALBP; GALIG; MAC2; 35 kDa lectin; Carbohydrate-binding protein 35; Galactose-specific lectin 3; Galactoside-binding protein; Laminin-binding protein; Lectin L-29

SPN	T817
HGNC	6563
MGI	96778
PubMed	20713592
RGD	69356
UniProt	P17931
Wiki	Galectin-3

Galectin-3 contains a carboxyl-terminal lectin domain and an amino-terminal non-lectin part consisting primarily of short tandem repeats. It is widely distributed in tissues and found in epithelial cells, fibroblasts, dendritic cells, and inflammatory cells.

In many cell types studied, galectin-3 is present diffusely in the cytoplasm, but is also localized to the nucleus and subcellular structures, such as mitochondria, phagosomes and exosomes, under specific conditions. It is secreted by various cell types, including monocytes, macrophages, and epithelial cells, and the extracellular protein can bind to a large number of different glycoconjugates on the cell surfaces and extracellular matrices.

Reference

"Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms."
Biochemistry 29:8093-8100(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a human macrophage lectin specific for galactose."
Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990) [PubMed] [Europe PMC] [Abstract]

"Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen."
Gene 99:279-283(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and chromosomal mapping of a human galactoside-binding protein."
Cancer Res. 51:2173-2178(1991) [PubMed] [Europe PMC] [Abstract]

"Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma."
Proc. Natl. Acad. Sci. U.S.A. 90:3466-3470(1993) [PubMed] [Europe PMC] [Abstract]

"The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter."
Arch. Biochem. Biophys. 349:7-20(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I."
J. Biol. Chem. 268:26712-26718(1993) [PubMed] [Europe PMC] [Abstract]

"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]

"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]

"The regulation of inflammation by galectin-3."
Immunol. Rev. 230:160-171(2009) [PubMed] [Europe PMC] [Abstract]

"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]

"Dynamics of galectin-3 in the nucleus and cytoplasm."
Biochim. Biophys. Acta 1800:181-189(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution."
J. Biol. Chem. 273:13047-13052(1998) [PubMed] [Europe PMC] [Abstract]