Tankyrase 2 (TNKS2)

PARP5B; PARP5C; TANK2; TNKL; Tankyrase-like protein; ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2

SPN	T794
HGNC	15677
MGI	1921743
PubMed	22449978
RGD	1305026
UniProt	Q9H2K2
Wiki	TNKS2

The poly(ADP-ribose) polymerase (PARP) tankyrase-1 contains an ankyrin-repeat domain that binds to various partners, including the telomeric protein TRF1 (telomere-repeat-binding factor 1) and the vesicular protein IRAP (insulin-responsive aminopeptidase). TRF1 binding recruits tankyrase-1 to telomeres and allows its PARP activity to regulate telomere homoeostasis. By contrast, IRAP binding and the Golgi co-localization of tankyrase-1 with IRAP might allow tankyrase-1 to affect the targeting ofIRAP-containing vesicles. A closely related protein, tankyrase-2, has also been implicated in vesicular targeting. Unlike tankyrase-1, tankyrase-2 has not been shown to have PARP activity. In addition, it has not been implicated in telomere homoeostasis, because it did not interact with TRF1 in previous studies.

Reference

"Novel tankyrase-related gene detected with meningioma-specific sera."
Clin. Cancer Res. 7:113-119(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of TNKL, a member of tankyrase gene family."
Genes Immun. 2:52-55(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14."
J. Biol. Chem. 276:17172-17180(2001) [PubMed] [Europe PMC] [Abstract]

"TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression."
J. Biol. Chem. 276:35891-35899(2001) [PubMed] [Europe PMC] [Abstract]

"Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)."
Biochem. J. 361:451-459(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres."
Mol. Cell. Biol. 22:332-342(2002) [PubMed] [Europe PMC] [Abstract]

"Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins."
Mol. Cell. Proteomics 8:535-546(2009) [PubMed] [Europe PMC] [Abstract]

"Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling."
Nature 461:614-620(2009) [PubMed] [Europe PMC] [Abstract]

"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]

"RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."
PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]

"Proteasome regulation by ADP-ribosylation."
Cell 153:614-627(2013) [PubMed] [Europe PMC] [Abstract]

"Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains."
FEBS J. 278:1086-1097(2011) [PubMed] [Europe PMC] [Abstract]