Methionyl tRNA Synthetase (MARS)

METRS; MTRNS; MetRS; Methionine tRNA Ligase 1,Cytoplasmic

SPN	T778
HGNC	6898
MGI	1345633
PubMed	11732605
UniProt	P56192
Wiki	MARS

Methionyl-tRNA synthetase, cytoplasmic is an enzyme .Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases.

Lage and Dietel (1996) isolated a human methionyl-tRNA synthetase cDNA from a gastric carcinoma cell line. The nucleotide sequence predicts a 900-amino acid protein with a molecular mass of 101 kD. The human gene is homologous (33.4% overall identity) to the yeast methionyl-tRNA synthetase gene.Methioninyl-tRNA synthetase has been mapped to chromosome 12 by study of somatic cell hybrids between human peripheral leukocytes and a temperature-sensitive Chinese hamster ovary line with an altered MTRNS.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Hu01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Hu01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Hu01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Hu01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Hu01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Mu01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Mu01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Mu01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Mu01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Mu01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Ra01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Ra01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Ra01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Ra01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Ra01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Ca01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Ca01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Ca01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Ca01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Ca01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Po01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Po01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Po01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Po01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Po01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Bo01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Bo01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Bo01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Bo01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Bo01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Rb01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Rb01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Rb01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Rb01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Rb01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT778Mo01	Recombinant Methionyl tRNA Synthetase (MARS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT778Mo01	Monoclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IP.
Antibodies	PAT778Mo01	Polyclonal Antibody to Methionyl tRNA Synthetase (MARS)	WB; IHC; ICC; IF.
Assay Kits	CLT778Mo01	CLIA Kit for Methionyl tRNA Synthetase (MARS)	CLIA assay for Antigen Detection
Assay Kits	ELT778Mo01	ELISA Kit for Methionyl tRNA Synthetase (MARS)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase."
Gene 178:187-189(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structures of the WHEP-TRS domain of human methionyl-tRNA synthetase."
Submitted (OCT-2006) to the PDB data bank

"Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype."
BMC Med. Genet. 14:106-106(2013) [PubMed] [Europe PMC] [Abstract]