Glutamyl Prolyl tRNA Synthetase (EPRS)

PARS; EARS; PIG32; QPRS; QARS; Bifunctional Aminoacyl-TRNA Synthetase; Glutamate tRNA Ligase; Proline tRNA Ligase; Cell proliferation-inducing gene 32 protein

SPN	T775
HGNC	3418
MGI	97838
PubMed	15479637
RGD	1310952
UniProt	P07814
Wiki	EPRS

Alternative splicing has been observed for Glutamyl-PARS), but the full-length nature and biological validity of the variant have not been determined.

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.Phosphorylation of EPRS is reported to be essential for the formation of GAIT (Gamma-interferon Activated Inhibitor of Translation) complex that regulates the translation of multiple genes in monocytes and macrophages.

Reference

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