Ryanodine Receptor 2, Cardiac (RYR2)
RYR-2; ARVD2; ARVC2; VTSIP; Arrhythmogenic Right Ventricular Dysplasia 2; Cardiac muscle ryanodine receptor-calcium release channel
- Ryanodine receptors (RyRs) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. It is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells.
- Ryanodine receptor 2 is a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with catecholaminergic polymorphic ventricular tachycardia, stress-induced polymorphic ventricular tachycardia, and arrhythmogenic right ventricular dysplasia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Hu01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Hu01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Hu01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Hu01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Hu01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Mu01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Mu01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Mu01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Mu01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Mu01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Ra01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Ra01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Ra01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Ra01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Ra01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Ca01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Ca01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Ca01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Ca01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Ca01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Po01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Po01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Po01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Po01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Po01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Bo01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Bo01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Bo01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Bo01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Bo01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Rb01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Rb01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Rb01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Rb01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Rb01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT759Mo01 | Recombinant Ryanodine Receptor 2, Cardiac (RYR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT759Mo01 | Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IP. |
| PAT759Mo01 | Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT759Mo01 | CLIA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | CLIA assay for Antigen Detection |
| ELT759Mo01 | ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis."
Biochem. J. 318:477-487(1996) [PubMed] [Europe PMC] [Abstract]
"Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)."
Hum. Mol. Genet. 10:189-194(2001) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium."
Biochem. J. 322:777-783(1997) [PubMed] [Europe PMC] [Abstract]
"Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum."
Neuroscience 85:205-216(1998) [PubMed] [Europe PMC] [Abstract]
"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts."
Cell 101:365-376(2000) [PubMed] [Europe PMC] [Abstract]
"S100A1 and calmodulin compete for the same binding site on ryanodine receptor."
J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]
"CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation."
Circ. Res. 106:1134-1144(2010) [PubMed] [Europe PMC] [Abstract]
"Cardiac excitation-contraction coupling."
Nature 415:198-205(2002) [PubMed] [Europe PMC] [Abstract]
"Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right."
Front. Biosci. 14:5134-5156(2009) [PubMed] [Europe PMC] [Abstract]
"Modulation of ryanodine receptor Ca2+ channels."
Mol. Med. Report. 3:199-204(2010) [PubMed] [Europe PMC] [Abstract]
"Ryanodine receptors: structure, expression, molecular details, and function in calcium release."
Cold Spring Harb. Perspect. Biol. 2:E3996-E3996(2010) [PubMed] [Europe PMC] [Abstract]
"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia."
Circulation 103:196-200(2001) [PubMed] [Europe PMC] [Abstract]
"Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia."
Circulation 103:485-490(2001) [PubMed] [Europe PMC] [Abstract]
"Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia."
Circulation 106:69-74(2002) [PubMed] [Europe PMC] [Abstract]
"Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers."
J. Am. Coll. Cardiol. 40:341-349(2002) [PubMed] [Europe PMC] [Abstract]
"Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms."
Eur. J. Hum. Genet. 11:888-891(2003) [PubMed] [Europe PMC] [Abstract]
"Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes."
Circulation 110:2119-2124(2004) [PubMed] [Europe PMC] [Abstract]
"Gene symbol: RYR2. Disease: effort-induced polymorphic ventricular arrhythmias."
Hum. Genet. 114:404-404(2004) [PubMed] [Europe PMC] [Abstract]
"Gene symbol: RYR2. Disease: effort-induced polymorphic ventricular arrhythmias."
Hum. Genet. 114:405-405(2004) [PubMed] [Europe PMC] [Abstract]
"Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases."
Mayo Clin. Proc. 79:1380-1384(2004) [PubMed] [Europe PMC] [Abstract]
"Loss of luminal Ca(2+) activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death."
Proc. Natl. Acad. Sci. U.S.A. 104:18309-18314(2007) [PubMed] [Europe PMC] [Abstract]