Carbonic Anhydrase XII (CA12)

CA-XII; CAXII; Carbonate dehydratase XII; Tumor antigen HOM-RCC-3.1.3

SPN	T707
HGNC	1371
MGI	1923709
PubMed	21035102
RGD	1306612
UniProt	O43570
Wiki	CA12

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.

Carbonic Anhydrase XII is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas.Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.

Reference

"Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers."
Proc. Natl. Acad. Sci. U.S.A. 95:7608-7613(1998) [PubMed] [Europe PMC] [Abstract]

"Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes."
Proc. Natl. Acad. Sci. U.S.A. 95:12596-12601(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]

"Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]

"Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II."
J. Am. Chem. Soc. 129:5528-5537(2007) [PubMed] [Europe PMC] [Abstract]

"A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]

"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
Proteins 74:164-175(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells."
Proc. Natl. Acad. Sci. U.S.A. 98:9545-9550(2001) [PubMed] [Europe PMC] [Abstract]

"Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII."
Am. J. Hum. Genet. 87:713-720(2010) [PubMed] [Europe PMC] [Abstract]