Carbonic Anhydrase XIII (CA13)

CA-XIII; CAXIII; Carbonate dehydratase XIII

SPN	T705
HGNC	14914
MGI	1931322
PubMed	18618712
RGD	1560453
UniProt	Q8N1Q1

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the rapid conversion of carbon dioxide to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion; they are therefore classified as metalloenzymes.the cytosolic CAs (CA-I, CA-II, CA-III, CA-VII and CA XIII)

Immunohistochemical analysis showed widespread expression of CA13 in human and mouse tissues, although its distribution differed between human and mouse. While CA13 was expressed at all stages of sperm development in human testis, it was not observed in mouse spermatozoa.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family."
J. Biol. Chem. 279:2719-2727(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
Proteins 74:164-175(2009) [PubMed] [Europe PMC] [Abstract]

"X-ray structure of human carbonic anhydrase 13 in complex with inhibitor."
Submitted (FEB-2009) to the PDB data bank