Hemoglobin Gamma 1 (HBg1)

HB-G1; HBGA; HBGR; HSGGL1; Gamma-1-globin

SPN	T693
HGNC	4831
MGI	96024
PubMed	24144231
RGD	620306
UniProt	P69891
Wiki	HBG1

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood.

The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Hu01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Hu01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Hu01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Hu01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Hu01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Mu01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Mu01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Mu01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Mu01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Mu01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Ra01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Ra01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Ra01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Ra01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Ra01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Ca01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Ca01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Ca01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Ca01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Ca01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Po01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Po01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Po01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Po01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Po01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Bo01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Bo01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Bo01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Bo01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Bo01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Rb01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Rb01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Rb01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Rb01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Rb01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT693Mo01	Recombinant Hemoglobin Gamma 1 (HBg1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT693Mo01	Monoclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IP.
Antibodies	PAT693Mo01	Polyclonal Antibody to Hemoglobin Gamma 1 (HBg1)	WB; IHC; ICC; IF.
Assay Kits	CLT693Mo01	CLIA Kit for Hemoglobin Gamma 1 (HBg1)	CLIA assay for Antigen Detection
Assay Kits	ELT693Mo01	ELISA Kit for Hemoglobin Gamma 1 (HBg1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes."
Cell 21:627-638(1980) [PubMed] [Europe PMC] [Abstract]

"A history of the human fetal globin gene duplication."
Cell 26:191-203(1981) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"The M gamma chain of human fetal hemoglobin is an A gamma chain with an in vitro modification of gamma 141 leucine to hydroxyleucine."
J. Chromatogr. A 617:37-42(1993) [PubMed] [Europe PMC] [Abstract]

"Haemoglobin level, proportion of haemoglobin Bart's and haemoglobin Portland in fetuses affected by homozygous alpha0-thalassemia from 12 to 40 weeks' gestation."
Prenat. Diagn. 30:1126-1130(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Hemoglobin F level in different hemoglobin variants."
Korean J. Hematol. 46:118-122(2011) [PubMed] [Europe PMC] [Abstract]

"Fetal hemoglobin levels and morbidity in untransfused patients with beta-thalassemia intermedia."
Blood 119:364-367(2012) [PubMed] [Europe PMC] [Abstract]

"Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia."
Protein Sci. 10:1739-1749(2001) [PubMed] [Europe PMC] [Abstract]

"Human fetal hemoglobin F 1. Acetylation status."
J. Biol. Chem. 246:3001-3007(1971) [PubMed] [Europe PMC] [Abstract]

"Hb F-Baskent or alpha 2A gamma 128(H6)Ala-->Thr."
Hemoglobin 12:87-89(1988) [PubMed] [Europe PMC] [Abstract]

"Hb F-Beech Island or alpha 2A gamma 2(53)(D4)Ala-->Asp."
Hemoglobin 9:525-529(1985) [PubMed] [Europe PMC] [Abstract]

"Hb F-Bonaire-Ga or alpha 2 A gamma 2 39(C5) Gln replaced by Arg, characterized by high pressure liquid chromatographic and microsequencing procedures."
Hemoglobin 6:599-606(1982) [PubMed] [Europe PMC] [Abstract]

"Hb F-Calluna or alpha 2 gamma 2(12 Thr replaced by Arg; 75Ile; 136Ala) in a Caucasian baby."
Hemoglobin 7:563-566(1983) [PubMed] [Europe PMC] [Abstract]

"Hb F-Cobb or alpha(2)A gamma(2)37(C3)Trp-->Gly."
Hemoglobin 9:617-619(1985) [PubMed] [Europe PMC] [Abstract]

"Hb F-Dammam or alpha 2A gamma 2(79) (EF3) Asp-->Asn."
Hemoglobin 9:171-173(1985) [PubMed] [Europe PMC] [Abstract]

"Genetic haemoglobin abnormalities in about 9000 Black and 7000 White newborns; haemoglobin F Dickinson (Agamma97His-Arg), a new variant."
Br. J. Haematol. 28:515-524(1974) [PubMed] [Europe PMC] [Abstract]

"Hb F-Fukuyama or A gamma T43(CD2)Asp-->Asn."
Hemoglobin 13:93-96(1989) [PubMed] [Europe PMC] [Abstract]

"Haemoglobin F Hull (gamma-121 glutamic acid-->lysine), homologous with haemoglobins O Arab and O Indonesia."
BMJ 3:531-533(1967) [PubMed] [Europe PMC] [Abstract]

"Survey of cord blood hemoglobin in Japan and identification of two new gamma chain variants."
Hemoglobin 5:139-151(1981) [PubMed] [Europe PMC] [Abstract]

"Characterization of a new fetal hemoglobin variant, Hb F Izumi A gamma 6Glu replaced by Gly, by molecular secondary ion mass spectrometry."
Biochim. Biophys. Acta 749:244-248(1983) [PubMed] [Europe PMC] [Abstract]

"Haemoglobin F Jamaica (alpha-2 gamma-2 61 Lys leads to Glu; 136 Ala)."
Br. J. Haematol. 18:369-375(1970) [PubMed] [Europe PMC] [Abstract]

"Hb F-Jiangsu, the first gamma chain variant with a valine->methionine substitution: alpha 2A gamma 2 134(H12)Val->Met."
Hemoglobin 14:177-183(1990) [PubMed] [Europe PMC] [Abstract]

"A new gamma chain variant, HB F Kotobuki or AI gamma 6 (A3) Glu leads to Gly."
Hemoglobin 6:37-42(1982) [PubMed] [Europe PMC] [Abstract]

"Structural identification of haemoglobin F Kuala Lumpur: alpha2 gamma2 22(B4)Asp leads to Gly; 136 Ala."
Biochim. Biophys. Acta 322:224-230(1973) [PubMed] [Europe PMC] [Abstract]

"Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His-->Gln."
Hemoglobin 18:241-245(1994) [PubMed] [Europe PMC] [Abstract]

"Hb F-Pendergrass, an A gamma I variant with a Pro-->Arg substitution at position gamma 36(C2)."
Hemoglobin 9:73-77(1985) [PubMed] [Europe PMC] [Abstract]

"A new gamma chain variant: Hb F-Pordenone [gamma 6(A3) Glu replaced by Gln: 75ILE: 136ALA]."
Hemoglobin 6:397-401(1982) [PubMed] [Europe PMC] [Abstract]

"A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2."
Acta Haematol. 53:347-355(1975) [PubMed] [Europe PMC] [Abstract]

"Hb F-Siena (alpha 2 a gamma t2 121 (GH4) Glu leads to Lys). A new fetal hemoglobin variant."
Hemoglobin 7:79-83(1983) [PubMed] [Europe PMC] [Abstract]

"Haemoglobin F Texas I(alpha-2,gamma-2-5glu-lys): a variant of haemoglobin F."
Br. J. Haematol. 13:252-255(1967) [PubMed] [Europe PMC] [Abstract]

"Haemoglobin F Victoria Jubilee (alpha 2 A gamma 2 80 Asp-Try)."
Biochim. Biophys. Acta 393:188-194(1975) [PubMed] [Europe PMC] [Abstract]

"Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations."
Hemoglobin 15:349-379(1991) [PubMed] [Europe PMC] [Abstract]

"Hb F-Xin-Su or A gamma I73(E17)Asp-->His: a new slow-moving fetal hemoglobin variant."
Hemoglobin 11:473-479(1987) [PubMed] [Europe PMC] [Abstract]

"Hb F-Xinjiang or A gamma T25(B7)Gly-->Arg: a new slow-moving unstable fetal hemoglobin variant."
Hemoglobin 11:465-472(1987) [PubMed] [Europe PMC] [Abstract]

"HB F-Yamaguchi (gamma 75Thr, gamma 80Asn, gamma 136Ala) is associated with G gamma-thalassemia."
Am. J. Hematol. 16:189-192(1984) [PubMed] [Europe PMC] [Abstract]