Hemoglobin Beta (HBb)

HB-B; HBD; CD113t-C; Beta Globin; Spinorphin

SPN	T688
HGNC	4827
MGI	96022
PubMed	10698297
RGD	2783
UniProt	P68871
Wiki	HBB

Beta globin (HBB, β-globin) is a protein that, along with alpha globin (HBA), makes up the most common form of hemoglobin in adult humans. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.

The gene is located in the β-globin locus. Expression of beta globin and the neighboring globins in the β-globin locus is controlled by single locus control region (LCR). The order of the genes in the beta-globin cluster is 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Hu01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Hu01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Hu01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Hu01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Hu01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Mu01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Mu01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Mu01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Mu01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Mu01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Ra01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Ra01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Ra01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Ra01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Ra01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Ca01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Ca01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Ca01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Ca01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Ca01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Po01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Po01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Po01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Po01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Po01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Bo01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Bo01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Bo01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Bo01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Bo01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Rb01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Rb01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Rb01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Rb01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Rb01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT688Mo01	Recombinant Hemoglobin Beta (HBb)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT688Mo01	Monoclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IP.
Antibodies	PAT688Mo01	Polyclonal Antibody to Hemoglobin Beta (HBb)	WB; IHC; ICC; IF.
Assay Kits	CLT688Mo01	CLIA Kit for Hemoglobin Beta (HBb)	CLIA assay for Antigen Detection
Assay Kits	ELT688Mo01	ELISA Kit for Hemoglobin Beta (HBb)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Nucleotide sequence analysis of coding and noncoding regions of human beta-globin mRNA."
Prog. Nucleic Acid Res. Mol. Biol. 19:165-175(1976) [PubMed] [Europe PMC] [Abstract]

"The nucleotide sequence of the human beta-globin gene."
Cell 21:647-651(1980) [PubMed] [Europe PMC] [Abstract]

"The beta-globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria."
Am. J. Hum. Genet. 77:637-642(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The constitution of normal adult human haemoglobin."
Hoppe-Seyler's Z. Physiol. Chem. 325:283-286(1961) [PubMed] [Europe PMC] [Abstract]

"Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin."
Nature 180:326-328(1957) [PubMed] [Europe PMC] [Abstract]

"Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings."
Biochem. Biophys. Res. Commun. 184:1060-1066(1992) [PubMed] [Europe PMC] [Abstract]

"Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated with severe hemolytic anemia."
Hemoglobin 5:97-105(1981) [PubMed&l