Low Density Lipoprotein Receptor Related Protein 2 (LRP2)

DBS; gp330; Glycoprotein 330; Megalin; Low Density Lipoprotein-Related Protein 2

SPN	T685
HGNC	6694
MGI	95794
PubMed	22340494
RGD	68407
UniProt	P98164
Wiki	LRP2

LRP2 is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins.

Reference

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Eur. J. Biochem. 239:132-137(1996) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)."
Genomics 22:88-93(1994) [PubMed] [Europe PMC] [Abstract]

"A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily."
Exp. Cell Res. 212:344-350(1994) [PubMed] [Europe PMC] [Abstract]

"Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin."
J. Biol. Chem. 270:13070-13075(1995) [PubMed] [Europe PMC] [Abstract]

"Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin."
Biochem. J. 347:613-621(2000) [PubMed] [Europe PMC] [Abstract]

"Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule."
J. Cell Sci. 116:453-461(2003) [PubMed] [Europe PMC] [Abstract]

"The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin."
Biochimie 86:179-182(2004) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes."
Nat. Genet. 39:957-959(2007) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]