Low Density Lipoprotein Receptor Related Protein 5 (LRP5)

HBM; BMND1; EVR1; EVR4; LR3; LRP7; OPPG; OPS; OPTA1; VBCH2; Osteoporosis Pseudoglioma Syndrome; Exudative Vitreoretinopathy 1

SPN	T684
HGNC	6697
MGI	1278315
PubMed	11719191
RGD	1309329
UniProt	O75197
Wiki	LRP5

LRP5 expression by osteoblasts in situ and showed that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. They further showed that a mutant secreted form of Lrp5 could reduce bone thickness in mouse calvarial explant cultures. These data indicated that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.LRP5 gene contains 23 coding exons and spans more than 100 kb. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene.

Reference

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